MBS 350 Bioinformatics • 5 Cr.
Topics include protein and DNA sequence alignments, evolutionary analysis and phylogenetic trees, obtaining protein secondary structure from sequence, and analysis of gene expression including clustering methods. Prerequisite: MBS 340 or equivalent, with a C or higher.
After completing this class, students should be able to:
- Access sequence data on appropriate databases for DNA, RNA and proteins.
- Explain and perform pairwise and multiple alignment methods.
- Understand and use BLAST (Basic Local Alignment Search Tool) proficiently, together with some more advanced related programs.
- Apply different computational strategies used to predict the 3D structure of new proteins.
- Explain the experimental techniques used in expressional and functional proteomics and the role of bioinformatics in analyzing the data.
- Perform motif and domain searches in protein databases.
- Explain microarray technology and microarray data analysis.