MBS 350 Bioinformatics • 5 Cr.


Topics include protein and DNA sequence alignments, evolutionary analysis and phylogenetic trees, obtaining protein secondary structure from sequence, and analysis of gene expression including clustering methods. Prerequisite: MBS 340 or equivalent, with a C or higher.


After completing this class, students should be able to:

  • Access sequence data on appropriate databases for DNA, RNA and proteins.
  • Explain and perform pairwise and multiple alignment methods.
  • Understand and use BLAST (Basic Local Alignment Search Tool) proficiently, together with some more advanced related programs.
  • Apply different computational strategies used to predict the 3D structure of new proteins.
  • Explain the experimental techniques used in expressional and functional proteomics and the role of bioinformatics in analyzing the data.
  • Perform motif and domain searches in protein databases.
  • Explain microarray technology and microarray data analysis.